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1002 – The first monastery on the territory of present-day Romania was at Morisena (today Cenad Village, Timis County). Its patron saint was St. John the Baptist and it was a monastery of Orthodox monks.

1030 – The first school on the current Romanian territory was opened at Cenad (Timis County). The teaching language was Latin.

About 1179 – the Abbey at Igris, founded by the Cistercian monks of the Pontigny Abbey in Burgundy, sheltered the first library on the Romanian territory, containing works of philosophy, theology etc. The library contained works of Cicero, Suetonius, Seneca and Quintilian.

1365 – Timisoara was the first town in mediaeval Hungary to receive a coat of arms by royal donation (from Louis I, also called “the Great” / I. Nagy Lajos). The figure on the coat of arms was a dragon.

1700 – An anonymous native of Banat (Anonymus Caransebesiensis or Lugoshiensis) wrote a Romanian-Latin dictionary entitled “Dictionarium vallachico-latinum”, the first bilingual lexicography work based on the Romanian language. Some researchers attributed the dictionary to Mihail Halici (1643-1712?). 
1718 – The first brewery in Romania was opened in Timisoara. 
1718 – The first copper melting furnace was built at Ciclova. It was the first industrial objective on the territory of the mountainous Banat.

1719 – The first furnace on the territory of the present-day Romania was built at Bocsa Montana.

1728 – The sewerage works of the Bega started; it is the first navigable canal in contemporary Romania

1729 – On January 22, the first vocational school for mining engineers opened at Oravita. It was the first mining engineering school not only in Romania, but also in Eastern Europe. The next such schools opened in 1741, at Dognecea, Moldova Noua and Sasca Montana.

1745 – Timisoara town hospital was opened (24 years before the one in Vienna and 35 years before the one in Budapest).

1753 – Timisoara organised the first permanent theatrical season (the third after Vienna and Budapest). 
1760 – Timisoara became the first town of the Habsburg Empire where public lighting with oil lamps was introduced. 
1771 – On April 18, Timisoara published the first newspaper that appeared on the current territory of Romania, “Temeswarer Nachrichten“ (the first German newspaper in Eastern Europe). 
1771 – Resita had the first two operation pig iron furnaces. Research work was started in the region and coal deposits were discovered at Doman and Secu.

1796 – At Oravita, the famous Knoblauch family of pharmacists founded the first “mine pharmacy” in Romania. 
1801 – The third agricultural school in the Habsburg Monarchy, which was also the first in Romania, was opened at Sannicolau Mare.

1815 – In Timisoara, Iosif Klapka’s library became the first lending library in the Habsburg Empire, the Kingdom of Hungary and the Romanian territory. 
1817 – The “Mihai Eminescu” Theatre House was inaugurated at Oravita. It is the oldest theatre in the country, the first stone theatre in Eastern Europe and the first building in Europe lit with acetylene gas lamps.

1819 – The vaccine against smallpox was administered in Timisoara for the first time in Central Europe.

1823 – Bolyai János announced, in Timisoara, the discovery of the first non-Euclidean geometry in the world. 
1843 – Timisoaraopened the first nursery school in Romania.  
1847 – Johann Strauss, Jr. performed his first concert outside Vienna at the Brewery in Timisoara.
1849 – The first railway station on the territory of today’s Romania was built at Oravita. 
1847 – On February 5, surgeons Mathyus Musil (1806-1889) and Joseph Siehs (1813-1850) performed the first anaesthesia with sulphuric ether at the military hospital of Timisoara before a thigh amputation intervention.

1850 – The first stamps of contemporary Romanian appeared in Banat.
1854 – On August 20, the 62.5-km railway Oravita-Bazias was inaugurated. Used only for coal transportation, it was the first railway built on the territory of today’s Romania. It was called the “Coalminers’ Line”. On November 1 1856, it was opened to passenger transport as well. 
1857 – Timisoara was the first town in the Habsburg Empire with gas street lighting. 
1863 – Oravita-Anina, the first mountain railway in contemporary Romania, was finished. 
1869 – July 8-12 – the first horse-drawn tram in Romania crossed the streets of Timisoara. 
1884 – November 24 – Timisoara became the first European town with electric street lighting. 
1884 – Timisoara had the first railway station with electric lighting in Europe, before Paris and Vienna.  
1886 – The first Ambulance Station in Hungary and contemporary Romania was set up in Timisoara.  
1895 – Timisoara had the first asphalt road in Romania. 
1899 – The first electric tram of contemporary Romania ran on the street of Timisoara. 
1902 – The first football match in Romania was played in Timisoara. 
1906 – On March 18, at Monteson, France, the Romanian Traian Vuia performed the first flight with an aircraft using its own on board devices for takeoff and landing.
1921 – The first Romanian lighting fixture company, “DURA – Barta & Co. Electrotechnical and Technical Company”, was set up in Timisoara.
1928 – On October 21-22, the first Romanian professional football association, F.C. Ripensia, was created in Timisoara. Ripensia was the first professional football team in the country. 
1930 – On July 14, Adalbert Georg Deschu from Gataia (Timis County) scored Romania’s first goal at the world football championship held in Montevideo, Uruguay.
1930 - Rudolf "Rudy“ Wetzer (Wetzer I), born in Timisoara, was the first Romanian professional football player; he was also the player who scored the most goals in an international game: five goals in the Romania - Greece game (8-1), played in Bucharest on May 25, 1930, during the “Balcaniada“ competition. 
1938 – Timisoara produced the first rail welding equipment in the world. 
About 1940 – Timisoara was the first Romanian town where the game Go was played.
1953 - Timisoara was the only European town with three state theatres: Romanian, German and Hungarian. 
1961 – MECIPT-1 was the first computer of the first generation made in the Romanian academic environment and among the first made in Europe. It was produced at the Polytechnic Institute of Timisoara. 
1969–  Professor Ghermanescu published in Timisoara the first treatise on functional equations in the world.  
1989 – The first animal clone in Romania was obtained in Banat, by Professor Ioan Vintila, a specialist in biotechnology.
1989 – Timisoara became the first town free of communism in Romania. 
1992 – The first laparoscopic interventions in gynaecology and the first breast plastic surgery with prosthesis were performed in Timisoaraby Professor I. Munteanu, in co-operation with the Heidelberg Clinic.

1992 – In Timisoara, Liviu Butoi inaugurated the first private jazz club in Romania, „Jazz Club Pod 16”. 
1993 – In Timisoara, the first total laparoscopic hysterectomy was performed by Professor I. Munteanu, in co-operation with the Clinic in Kiel).  
1995 – The first in vitro fertilisation and the first human embryo transfer in Romania were performed in Timisoara; the first Laparoscopy, Laparoscopic Surgery and in vitro Fertilization Centre in Romania was opened in Timisoara.

1995 –"Bega Blues Band“ of Timisoara recorded the first blues-jazz CD-ROM in Romania. 
1996 – The first Romanian baby conceived in vitro was born in Timisoara.  
2000 – The first electronic payment of customs duties in Romania was made with the help of a software application developed by the Timisoara branch of Forte-Siemens Company.

2001 – The first infokiosk network in Romania was established in Timisoara. 
2001 – The first laser heart surgery in Romania took place in Timisoara. 
2001 – Timisoara implemented the system of online tax payment for the first time in Romania.
2005 – At Johnny Bota’s initiative, Richard Oschanitzky Faculty of Jazz and Pop was set up in Timisoara, the first faculty of the kind in the country.

2007 – On March 14, in Timisoara, the TELPARK service launched the most modern and easy-to-use method of paying parking fees via the mobile phone.

2007 – On March 15, for the first time in Romania, Banat Media-Verlag für elektronische Medien from Germany and the Project Ratsko Association Timisoara launched a postcard with an encased mini CD-ROM. The action was part of the Banaterra Project (www.banaterra.eu), under the name of “Discover Banat“. The postcard can be used as such, and the mini CD includes over 200 old postcards from the collection of Thomas Remus Mochnacs, a historian native of Timisoara, an SVCD videoclip (metamorphoses) for DVD-player and a photo album.